(F) Multiple CK2 motifs increase substrate affinity for KBTBD8

(F) Multiple CK2 motifs increase substrate affinity for KBTBD8. multisite dependency of an E3 ligase provides a powerful mechanism for switch-like cell fate transitions controlled by monoubiquitylation. account for?~90% of cases of the craniofacial disease Treacher Collins Syndrome (The Treacher Collins Syndrome Colla, 1996; Jones et al., 2008), while additional transcription factor binding sites in …
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