These observations prompted us to investigate in greater detail whether protein synthesis inhibitors induce death inside a wider range of cell types and evaluate the role of the Bax/Bak-mediated apoptotic pathway in mediating the cytotoxicity of these compounds

These observations prompted us to investigate in greater detail whether protein synthesis inhibitors induce death inside a wider range of cell types and evaluate the role of the Bax/Bak-mediated apoptotic pathway in mediating the cytotoxicity of these compounds. Open in a separate window Figure 1 Human being CLL cells and many leukemia or lymphoma-derived cell …
Continue reading These observations prompted us to investigate in greater detail whether protein synthesis inhibitors induce death inside a wider range of cell types and evaluate the role of the Bax/Bak-mediated apoptotic pathway in mediating the cytotoxicity of these compounds

The passive uptake in mock cells was subtracted from the total uptake in the OATP1B1 expressing cells at each inhibitor concentration

The passive uptake in mock cells was subtracted from the total uptake in the OATP1B1 expressing cells at each inhibitor concentration. endogenous compounds, such as bile acids, in parallel with, e.g., the bile acid transporter Na+-taurocholate co-transporting polypeptide (NTCP, models suggested the observed increase in the AUC was related to the inhibition of OATP1B1 (14). …
Continue reading The passive uptake in mock cells was subtracted from the total uptake in the OATP1B1 expressing cells at each inhibitor concentration