Frank AK, Tran DC, Qu RW, Stohr BA, Segal DJ, Xu L

Frank AK, Tran DC, Qu RW, Stohr BA, Segal DJ, Xu L. provide the first evidence that the IFD can mediate enzyme processivity and telomerase recruitment to telomeres in a TPP1-dependent manner. Moreover, unlike hTERT-V791Y, hTERT-V763S, a variant with reduced activity but increased processivity, AVL-292 and hTERT-L805A, could both immortalize limited-life-span cells, but cells expressing …
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The cells were taken care of inside a humidified environment of 5% CO2/95% air at 37C as referred to previously

The cells were taken care of inside a humidified environment of 5% CO2/95% air at 37C as referred to previously.25,26,27 The cell lines were cultured in 60 cm2 cells culture meals and were 80% confluent at period of treatment. Cell Treatment with Inhibitors 10A, 10AT, 10ATG3B and 10CA1a cells were treated with 500 nM of …
Continue reading The cells were taken care of inside a humidified environment of 5% CO2/95% air at 37C as referred to previously

Lataillade et al

Lataillade et al. ability of HSCs in G1 phase to engraft to irradiated recipients is definitely lost in adult bone marrow. (D) Administration of the CXCL12/CXCR4 antagonist SDF-1G2 into recipient mice prior to transplantation enables S/G2/M HSCs from fetal liver, postnatal bone marrow, and possibly (question mark) adult bone marrow to engraft in recipient mice. …
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