Further studies are needed to confirm this. In conclusion, our findings suggested that detection of antibodies showed huge value in helping diagnosis of COVID-19 infection. male, 31% female), who have been admitted to Jin-Yin-Tan Hospital between 30 December, 2019 and 15 January, 2020 with mean 9 ( 3.9) days after onset of sign. The average age was 51.4 ( 11.8) years and 17.5% patients were more than 60. All individuals were occupants of Wuhan or surrounding areas.?75 (57%) individuals had a history of exposure to the Huanan Seafood Market, 12 (9%) cases had exposure to individuals with confirmed or highly suspected COVID-19, CEP dipeptide 1 and 9 (7%) individuals were clustered onset. Among those 131 individuals, 55 (42%) experienced underlying chronic diseases, including 31 (24%) hypertension, 14 (11%) diabetes and 7 (5%) with chronic heart disease. Table?1 Demographics and clinical characteristics of the included individuals.
Sex (Male/Woman)90 (68.7%)/41 (31.3%)Age, years51.4??11.8 (24C81)Age range, years?24C3919 (14.5%)?40C5976 (58.0%)?60C7935 (16.7%)??801 (0.8%)Days from onset to hospitalization9.04??3.93 (1C24)Time of staying in hospital (days)18.26??10.06 (4C72)Normal/severe/critical instances15 (11.4%)/82 (62.6%)/34 (26.0%)Comorbidities55 (42%)?Hypertension31 (23.7%)?Diabetes mellitus14 (10.7%)?Heart disease7 (5.3%)Epidemiologic history?History of residence or travel131 (100%)?Exposure to Huanan Seafood Wholesale Market75 (57.3%)?History of contacting with COVID-19 individuals12 (9.2%)?Clustered onset9 (6.9%)Onset symptoms?Fever124 (94.7%)?Cough96 (73.3%)?Dyspnea50 (38.2%)?Fatigue43 (32.8%)?Shortness of breath33 (25.2%)?Gasping22 (16.8%)?Muscle mass ache20 (15.3%)?Headache15 (11.5%)?Chill12 (9.2%)?Chest pain7 (5.3%)?Nausea5 (3.8%)?Dizziness5 (3.8%)?Sore throat4 (3.1%)?Runny nose4 (3.1%)?Difficulty deep breathing4 (3.1%)?Joint soreness4 (3.1%)?Palpitations3 (2.3%)?Vomit3 (2.3%)?Shivering3 (2.3%)?Diarrhea2 (1.5%)Treatment?Glucocorticoids64 (48.9%)?Immunoglobulin19 (14.5%)?High-flow Nose Cannula33 (25.2%)?Non-invasive ventilation16 (12.2%)?Invasive ventilation7 (5.3%)?Extracorporeal membrane oxygenation4 (3.1%)?Renal replacement therapy6 (4.6%)?Blood transfusion4 (3.1%)?Vasoconstrictive agents4 (3.1%)Complication72 (55.0%)?Liver dysfunction48 (36.6%)?Acute respiratory stress syndrome40 (30.5%)?Hypoproteinemia34 (26.0%)?Sepsis18 (13.7%)?Thrombocytopenia16 (12.2%)?Acute kidney injury13 (9.9%)?Septic shock11 (8.4%)?Acute myocardial injury9 (6.9%)In-hospital mortality15 (11.5%) Open in a separate window The most common symptoms at admission were fever (124, 94.7%), cough (96, 73.3%) and dyspnea (50, 38.2%). A few individuals presented atypical onset symptoms, including headache (15, 12%), dizziness (5, 4%), nausea (5, 4%), vomit (3, 2%) and diarrhea (2, 1.5%). Almost half of the individuals (64, 49%) received glucocorticoids, 19 (14.5%) instances received human being immunoglobulin; 33 (25.5%) individuals were treated with high-flow nasal cannula, 23 (17.6%) with mechanical air flow, 4 (3.1%) with extracorporeal membrane oxygenation (ECMO), 6 (4.6%) with renal alternative therapy, and 4 (3.1%) with vasoconstrictive providers. More than half (72, 55.5%) of the individuals had damage in organ function, including 48 (36.6%) with liver dysfunction, 40 (30.5%) with CEP dipeptide 1 ARDS, 13 (9.9%) with acute kidney injury, 11 (8.4%) with septic shock, and 9 (6.9%) with acute cardiac injury. Most of the individuals (82, 62.6%) were severe instances and a quarter of individuals were critical instances according to the clinical classification defined by General Office of National Health Committee of China (General Office of National Health Committee 2020). Fifteen (11.5%) of those individuals died during hospitalization (Table?1). Laboratory Guidelines The majority of the individuals had a normal white blood cell count (88/131, 67.2%) and normal procalcitonin (123/128, 96.1%). More than half of the individuals had a reduced lymphocyte count (83/131, 63.4%), and increased signals of swelling, including ESR (120/127, 94.5%), C-reactive protein (107/128, 83.6%), interleukin 6 (49/97, 50.5%), LDH (85/128, 66.4%) and ferritin (86/119, 72.3%). Some individuals showed irregular coagulation function index, including improved fibrinogen (92/124, 74.2%) and increased D-Dimer (20/123, 16.3%) (Table?2). Table?2 Laboratory guidelines.
White colored blood cell count, ?109/L6.02??3.30??9.518/131 (13.7%)Neutrophil count, 109 /L4.66??3.38Lymphocyte count, 109 /L1.00??0.52?
